Glycyrrhetinic acid (Enoxolone)

15-PGDH inhibitor

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Catalog No. A10353

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Glycyrrhetinic acid 500mg A10353-500
$50.00
Glycyrrhetinic acid 2g A10353-2000
$160.00
Glycyrrhetinic acid 10mM * 1mL in DMSO A10353-10mM-D
$59.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Glycyrrhetinic acid inhibits the enzymes (15-hydroxyprostaglandin dehydrogenase and delta-13-prostaglandin) that metabolize the prostaglandins PGE-2 and PGF-2α to their respective 15-keto-13,14-dihydro metabolites which are inactive.

Glycyrrhetinic acid (Enoxolone)

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Chemical Information

Catalog Num A10353
Actions Inhibitor
M. Wt 470.7
Formula C30H46O4
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 471-53-4
Synonyms Enoxolone, Glycyrrhetin, Uralenic acid, Glycyrrhetinate, Arthrodont
SMILES code C[[email protected]]12CC[[email protected]](C[[email protected]]1C3=CC(=O)[[email protected]@H]4[[email protected]]5(CC[[email protected]@H](C([[email protected]@H]5CC[[email protected]]4([[email protected]@]3(CC2)C)C)(C)C)O)C)(C)C(=O)O
Chemical Name 3b-Hydroxy-11-oxo-18b,20b-olean-12-en-29-oic acid

Biological Activity

Description
Glycyrrhetinic acid inhibits the enzymes (15-hydroxyprostaglandin dehydrogenase and delta-13-prostaglandin) that metabolize the prostaglandins PGE-2 and PGF-2α to their respective 15-keto-13,14-dihydro metabolites which are inactive.
Targets
15-hydroxyprostaglandin dehydrogenase

Solubility

Solubility (25°C)* In vitro DMSO 94 mg/mL (199.71 mM)
Water <1 mg/mL (<1 mM)
Ethanol 94 mg/mL (199.71 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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