Go 6976

Catalog No.: A12419
PKC inhibitor
Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3.
Grouped product items
Product Name Stock
Go 6976 5mg
Go 6976 10mg
Go 6976 25mg
Go 6976 50mg
Go 6976 10mM * 1mL in DMSO
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Biological Activity
Discription Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3.
Targets
Target Value
Product Information
Catalog Num A12419
Formula C24H18N4O
Molecular Weight 378.43
CAS Number 136194-77-9
SMILES CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O
Synonyms Go6976, Go-6976
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO Warmed: 18 mg/mL (47.69 mM)
Water Insoluble
Ethanol Insoluble
In vivo 0.5% CMC Na+1% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.42 mL 132.12 mL 264.25 mL
0.5 mM 5.28 mL 26.42 mL 52.85 mL
1 mM 2.64 mL 13.21 mL 26.42 mL
5 mM 0.53 mL 2.64 mL 5.28 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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