GSK2126458

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mTOR/PI3K Inhibitor,

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Catalog No. A11035

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
GSK2126458 2mg A11035-2

Regular Price: $80.00

Special Price: $68.00

GSK2126458 5mg A11035-5

Regular Price: $120.00

Special Price: $102.00

GSK2126458 10mg A11035-10

Regular Price: $160.00

Special Price: $136.00

GSK2126458 50mg A11035-50

Regular Price: $420.00

Special Price: $357.00

GSK2126458 10mM * 1mL in DMSO A11035-10mM-D

Regular Price: $130.00

Special Price: $110.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

GSK2126458 is a highly potent, orally bioavailable inhibitor of PI3Kα and mTOR with in vivo activity in both pharmacodynamic and tumor growth efficacy models.

GSK2126458

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Chemical Information

Catalog Num A11035
Actions Inhibitor
M. Wt 505.5
Formula C25H17F2N5O3S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1086062-66-9
Synonyms GSK-2126458
SMILES code COC1=C(C=C(C=N1)C2=CC3=C(C=CN=C3C=C2)C4=CN=NC=C4)NS(=O)(=O)C5=C(C=C(C=C5)F)F
Chemical Name 2,4-Difluoro-N-{2-(methyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzenesulfonamide

Biological Activity

Description
GSK2126458 is a highly potent, orally bioavailable inhibitor of PI3Kα and mTOR with in vivo activity in both pharmacodynamic and tumor growth efficacy models.
Targets
Target Value
p110αki: 0.019nM
p110δki: 0.024nM
p110γki: 0.06nM
p110βki: 0.13nM
mTORC1ki: 0.18nM
mTORC2ki: 0.3nM

Solubility

Solubility (25°C) * In vitro DMSO 100 mg/mL (197.82 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 18 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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