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GSK2578215A

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LRRK2 kinase inhibitor

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Catalog No. A12798

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
GSK2578215A 10mg A12798-10

Regular Price: $60.00

Special Price: $48.00

GSK2578215A 25mg A12798-25

Regular Price: $120.00

Special Price: $96.00

GSK2578215A 50mg A12798-50

Regular Price: $230.00

Special Price: $184.00

GSK2578215A 100mg A12798-100

Regular Price: $400.00

Special Price: $320.00

GSK2578215A 10mM * 1mL in DMSO A12798-10mM-D

Regular Price: $87.00

Special Price: $69.60

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

GSK2578215A is a potent leucine-rich repeat kinase 2 (LRRK2) inhibitor (IC50 values are 8.9 and 10.1 nM respectively for LRRK2[G2019S] mutant and wild-type LRRK2 respectively).

GSK2578215A

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Chemical Information

Catalog Num A12798
Actions Inhibitor
M. Wt 399.42
Formula C24H18FN3O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1285515-21-0
Synonyms GSK-2578215A, GSK 2578215A
SMILES code C1=CC=C(C=C1)COC2=C(C=C(C=C2)C3=CC(=NC=C3)F)C(=O)NC4=CN=CC=C4
Chemical Name 5-(2-Fluoro-4-pyridinyl)-2-(phenylm?ethoxy)-N-3-pyridinylbenzamide

Biological Activity

Description
GSK2578215A is a potent leucine-rich repeat kinase 2 (LRRK2) inhibitor (IC50 values are 8.9 and 10.1 nM respectively for LRRK2[G2019S] mutant and wild-type LRRK2 respectively).
Targets
LRRK2 (G2019S) LRRK2 (WT)
8.9 nM10.9 nM

Solubility

Solubility (25°C)* In vitro DMSO 79 mg/mL heating (197.78 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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