GSK429286A

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ROCK Inhibitor

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Catalog No. A10441

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
GSK429286A 5mg A10441-5

Regular Price: $80.00

Special Price: $68.00

GSK429286A 25mg A10441-25

Regular Price: $208.00

Special Price: $176.80

GSK429286A 50mg A10441-50

Regular Price: $360.00

Special Price: $306.00

GSK429286A 100mg A10441-100

Regular Price: $580.00

Special Price: $493.00

GSK429286A 10mM * 1mL in DMSO A10441-10mM-D

Regular Price: $80.00

Special Price: $68.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

GSK429286A is a cell-permeable, selective small molecule inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK).

GSK429286A

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Chemical Information

Catalog Num A10441
Actions Inhibitor
M. Wt 432.4
Formula C21H16F4N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 864082-47-3
Synonyms GSK-429286A
SMILES code CC1=C(C(CC(=O)N1)C2=CC=C(C=C2)C(F)(F)F)C(=O)NC3=C(C=C4C(=C3)C=NN4)F
Chemical Name N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide

Biological Activity

Description
GSK429286A is a cell-permeable, selective small molecule inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK).
Targets
ROCK1 ROCK2
14 nM63 nM

Solubility

Solubility (25°C) * In vitro DMSO 87 mg/mL (201.21 mM)
Water <1 mg/mL (<1 mM)
Ethanol 4 mg/mL (9.25 mM)
In vivo 15% Captisol/citrate vehicle 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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