Target & Activity
| Target | Activity | Value |
|---|---|---|
| FXR (CV1) | EC50 | 65 nM |
Fig. 1 · Structure
Documents & Downloads
GW4064
Cat. No.
A11141
CAS
278779-30-9
FXR agonist
GW4064 is a selective, non-steroidal farnesoid X receptor (FXR) agonist (EC50 = 15 nM).
In Stock
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 278779-30-9 |
| Applications | FXR agonist |
| Formula | C28H22Cl3NO4 |
| Molecular Weight | 542.8 |
| SMILES | CC(C)C1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)COC3=CC(=C(C=C3)/C=C/C4=CC(=CC=C4)C(=O)O)Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 99 mg/mL (182.37 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
In Vivo Preparation
- Concentration
- 10 mg/mL
- Vehicle
- 0.5% methylcellulose
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Publications
2 publications citing this product
-
Dong-Hyun Kim, .et al. , Cell Death Dis, 2021, Apr; 12(4): 320 PMID: 33767132
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Takae K, .et al. , J Reprod Dev, 2018, Nov 16 PMID: 30449821