Icariin

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PDE5 inhibitor

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Catalog No. A10464

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Icariin 50mg A10464-50

Regular Price: $60.00

Special Price: $48.00

Icariin 100mg A10464-100

Regular Price: $100.00

Special Price: $80.00

Icariin 250mg A10464-250

Regular Price: $200.00

Special Price: $160.00

Icariin 500mg A10464-500

Regular Price: $320.00

Special Price: $256.00

Icariin 10mM * 1mL in DMSO A10464-10mM-D

Regular Price: $67.00

Special Price: $53.60

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Icariin is inhibitory to all three PDE5 isoforms that inhibits PDE5A1, A2, and A3 with an IC50 value of 1.0, 0.75, and 1.1 microM, respectively.

Icariin

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Chemical Information

Catalog Num A10464
Actions Inhibitor
M. Wt 676.7
Formula C33H40O15
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 489-32-7
Synonyms N/A
SMILES code C[[email protected]]1[[email protected]@H]([[email protected]]([[email protected]]([[email protected]@H](O1)OC2=C(OC3=C(C2=O)C(=CC(=C3CC=C(C)C)O[[email protected]]4[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]](O4)CO)O)O)O)O)C5=CC=C(C=C5)OC)O)O)O
Chemical Name 5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one

Biological Activity

Description
Icariin is inhibitory to all three PDE5 isoforms that inhibits PDE5A1, A2, and A3 with an IC50 value of 1.0, 0.75, and 1.1 microM, respectively.
Targets
PDE5
0.432 μM

Solubility

Solubility (25°C)* In vitro DMSO 50 mg/mL (73.89 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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