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Fig. 1 · Structure
Cat. No.
A14397
CAS No.
110117-83-4
Formula
C12H14N2O2
Mol. Weight
218.25

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Indoximod (NLG-8189)

Cat. No. A14397 CAS 110117-83-4

IDO inhibitor

Indoximod is a methylated tryptophan with anti-immunosuppressive activity.

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For laboratory research use only. We do not sell to patients.

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Biological Activity

Target & Activity

Target Activity Value
IDO Ki 19 μM

Cellular Effect

Cell Line Activity Value Description Reference
A549 IC50 > 100 μM Anticancer activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay [PMID: 31954880]
HeLa IC50 > 100 μM Anticancer activity against human HeLa cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay [PMID: 31954880]
HeLa EC50 110 μM Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells using L-tryptophan as substrate after 24 hrs [PMID: 28526475]
HUVEC IC50 > 100 μM Cytotoxicity against HUVEC cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay [PMID: 31954880]
PC-3 IC50 > 100 μM Anticancer activity against human PC3 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay [PMID: 31954880]
U-87MG ATCC IC50 148.9 μM Inhibition of recombinant human IDO2 expressed in human U87MG cells assessed as reduction in kynurenine formation using L-tryptophan as substrate after 6 hrs by spectrophotometry [PMID: 27475108]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 110117-83-4
Applications IDO inhibitor
Formula C12H14N2O2
Molecular Weight 218.25
Synonyms NLG8189; D-1MT
SMILES
CN1C=C(C2=CC=CC=C21)C[C@H](C(=O)O)N

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO Warmed: 1 mg/mL (4.58 mM)
Water Insoluble
Ethanol Insoluble

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

In Vivo Preparation

Concentration
0.1 mg/mL
Vehicle
5% DMSO+30% PEG 300+5% Tween 80+ddH2O

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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