IPI-145 (Duvelisib, INK1197)

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PI3K-δ/PI3K-γ inhibitor

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Catalog No. A12422

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
IPI-145 5mg A12422-5

Regular Price: $80.00

Special Price: $68.00

IPI-145 10mg A12422-10

Regular Price: $110.00

Special Price: $93.50

IPI-145 25mg A12422-25

Regular Price: $180.00

Special Price: $153.00

IPI-145 50mg A12422-50

Regular Price: $240.00

Special Price: $204.00

IPI-145 10mM * 1mL in DMSO A12422-10mM-D

Regular Price: $85.00

Special Price: $72.25

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

IPI-145, also known as INK-1197, is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities.

IPI-145 (Duvelisib, INK1197)

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Chemical Information

Catalog Num A12422
Actions Inhibitor
M. Wt 416.86
Formula C22H17ClN6O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1201438-56-3
Synonyms IPI145; IPI 145; IPI-145. INK-1197; INK 1197; INK1197
SMILES code C[[email protected]@H](C1=CC2=C(C(=CC=C2)Cl)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5
Chemical Name (S)-3-(1-((9H-purin-6-yl)amino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one

Biological Activity

Description
IPI-145, also known as INK-1197, is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities.
Targets
Target Value
PI3Kδki: 23pM
PI3Kγki: 243pM
PI3Kδki: 23pM
PI3Kβki: 1564pM
PI3Kαki: 25900pM
PI3Kγki: 243pM

Solubility

Solubility (25°C) * In vitro DMSO 84 mg/mL (201.5 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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