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|Storage||at -20°C 2 years|
|Chemical Name||2-?[[3-?(4-?fluorophenyl)-?3,?4,?6,?7-?tetrahydro-?4-?oxothieno[3,?2-? d]pyrimidin-?2-?yl]thio]-?N-?(6-?methyl-?2-?benzothiazolyl)-?acetamide|
|IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC₅₀ = 1.2 μM).|
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IWP-2 is an inactivator of Porcn function and inhibitor of Wnt production, and blocks beta-catenin accumulation. Wnt/b-catenin ('canonical') pathway maintains transcriptional programs that enable stem ...
Special Price Starting at: $42.50