JNJ-7706621

CDK/Aurora A/B Inhibitor

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Catalog No. A10494

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
JNJ-7706621 5mg A10494-5
$120.00
JNJ-7706621 10mg A10494-10
$210.00
JNJ-7706621 50mg A10494-50
$500.00
JNJ-7706621 100mg A10494-100
$860.00
JNJ-7706621 10mM * 1mL in DMSO A10494-10mM-D
$154.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.

JNJ-7706621

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Chemical Information

Catalog Num A10494
Actions Inhibitor
M. Wt 394.4
Formula C15H12F2N6O3S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 443797-96-4
Synonyms JNJ7706621
SMILES code C1=CC(=C(C(=C1)F)C(=O)N2C(=NC(=N2)NC3=CC=C(C=C3)S(=O)(=O)N)N)F
Chemical Name 4-[[5-Amino-1-(2,6-difluorobenzoyl)-1h-1,2,4-triazol-3-yl]amino]benzenesulfonamide

Biological Activity

Description
JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.

Solubility

Solubility (25°C) * In vitro DMSO 79 mg/mL (200.32 mM)
Water <1 mg/mL (<1 mM
Ethanol <1 mg/mL (<1 mM
In vivo 0.5% methylcellulose/0.2% Tween 80 14 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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