JNJ-7706621

Catalog No.: A10494
CDK/Aurora A/B Inhibitor
JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.
Grouped product items
Product Name Price Stock Qty
JNJ-7706621 5mg
$120.00
In stock
JNJ-7706621 10mg
$210.00
In stock
JNJ-7706621 50mg
$500.00
In stock
JNJ-7706621 100mg
$860.00
In stock
JNJ-7706621 10mM * 1mL in DMSO
$154.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's JNJ-7706621 has been cited by 1 publications
  • Yuta Tanizaki, .et al. , Commun Biol, 2022, 5: 112 PMID: 35132135
  • Biological Activity
    Discription JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.
    Targets
    Target Value
    Product Information
    Catalog Num A10494
    Formula C15H12F2N6O3S
    Molecular Weight 394.4
    CAS Number 443797-96-4
    SMILES C1=CC(=C(C(=C1)F)C(=O)N2C(=NC(=N2)NC3=CC=C(C=C3)S(=O)(=O)N)N)F
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 67 mg/mL (169.89 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 0.5% methylcellulose+0.2% Tween 80 13 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 25.35 mL 126.77 mL 253.55 mL
    0.5 mM 5.07 mL 25.35 mL 50.71 mL
    1 mM 2.54 mL 12.68 mL 25.35 mL
    5 mM 0.51 mL 2.54 mL 5.07 mL
    Useful Calculator

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