Linifanib (ABT-869)

Catalog No.: A10025
VEGFR/PDGFR inhibitor
Linifanib (ABT-869) is a structurally novel, potent inhibitor of RTK, VEGF and PDGF with IC50 of 0.2, 2, 4, and 7 nM for human endothelial cells, PDGFR-β, KDR, and CSF-1R, respectively.
Grouped product items
Product Name Price Stock Qty
Linifanib (ABT-869) 5mg
$40.00
In stock
Linifanib (ABT-869) 10mg
$70.00
In stock
Linifanib (ABT-869) 50mg
$200.00
In stock
Linifanib (ABT-869) 100mg
$350.00
In stock
Linifanib (ABT-869) 10mM * 1mL in DMSO
$89.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's Linifanib (ABT-869) has been cited by 2 publications
  • Ayaka Kojima, .et al. , Xenobiotica, 2022, Jul;52(7):669-675 PMID: 36251932
  • Li Li, .et al. , Leukemia Res, 2019, 78:12-20 PMID: 30660961
  • Biological Activity
    Discription Linifanib (ABT-869) is a structurally novel, potent inhibitor of RTK, VEGF and PDGF with IC50 of 0.2, 2, 4, and 7 nM for human endothelial cells, PDGFR-β, KDR, and CSF-1R, respectively.
    Targets
    Target Value
    Product Information
    Catalog Num A10025
    Formula C21H18FN5O
    Molecular Weight 375.4
    CAS Number 796967-16-3
    SMILES CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 73 mg/mL (194.45 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 5%DMSO+40%PEG 300+5%Tween80+50%ddH2O 9 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 26.64 mL 133.19 mL 266.38 mL
    0.5 mM 5.33 mL 26.64 mL 53.28 mL
    1 mM 2.66 mL 13.32 mL 26.64 mL
    5 mM 0.53 mL 2.66 mL 5.33 mL
    Useful Calculator

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    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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