Target & Activity
| Target | Activity | Value |
|---|---|---|
| 5-HT7 Receptor | IC50 | 0.495 nM |
| 5-HT1A Receptor | IC50 | 6.75 nM |
| D2 Receptor | IC50 | 1.68 nM |
Fig. 1 · Structure
Documents & Downloads
Lurasidone (SM13496)
Cat. No.
A11214
CAS
367514-87-2
Dopamine D2 inhibitor
Lurasidone is an atypical antipsychotic that alleviates positive symptoms (e.g., hallucinations, delusions) without inducing extrapyramidal side effects except for akathisia,despite its potent D2 antagonistic actions.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 367514-87-2 |
| Applications | Dopamine D2 inhibitor |
| Formula | C28H36N4O2S |
| Molecular Weight | 492.7 |
| Synonyms | SM13496 |
| SMILES | C1CC[C@H]([C@@H](C1)CN2CCN(CC2)C3=NSC4=CC=CC=C43)CN5C(=O)[C@H]6[C@@H]7CC[C@@H](C7)[C@H]6C5=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 7 mg/mL (14.2 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.