LY2140023 (LY404039)

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mGluR Agonist

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Catalog No. A10544

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
LY2140023 5mg A10544-5

Regular Price: $55.00

Special Price: $46.75

LY2140023 10mg A10544-10

Regular Price: $100.00

Special Price: $85.00

LY2140023 50mg A10544-50

Regular Price: $360.00

Special Price: $306.00

LY2140023 100mg A10544-100

Regular Price: $620.00

Special Price: $527.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

LY-404039 is a drug used in scientific research that acts as a selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3. It has anxiolytic and antipsychotic effects in animal studies, but without causing sedation. Early human trials using a prodrug form of LY-404,039 called LY-214,0023 have also given encouraging results.

LY2140023 (LY404039)

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Chemical Information

Catalog Num A10544
Actions Agonist
M. Wt 235.2
Formula C7H9NO6S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 635318-11-5
Synonyms LY-404039, LY-2140023
SMILES code C1[C@]([C@@H]2[C@H]([C@@H]2S1(=O)=O)C(=O)O)(C(=O)O)N
Chemical Name (1R,4S,5S,6S)-4-Amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide

Biological Activity

Description
LY-404039 is a drug used in scientific research that acts as a selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3. It has anxiolytic and antipsychotic effects in animal studies, but without causing sedation. Early human trials using a prodrug form of LY-404,039 called LY-214,0023 have also given encouraging results.
Targets
Rat neurons expressing native mGlu2/3 Recombinant human mGlu3 Recombinant human mGlu2
88 nM(Ki)92 nM(Ki)149 nM(Ki)

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