LY2784544 (Gandotinib)

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JAK inhibitor

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Catalog No. A10546

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
LY2784544 5mg A10546-5
$90.00
LY2784544 10mg A10546-10
$160.00
LY2784544 25mg A10546-25
$550.00
LY2784544 100mg A10546-100
$1,600.00
LY2784544 10mM * 1mL in DMSO A10546-10mM-D
$144.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

LY2784544 is identified as being highly selective for JAK2-V617F and has advanced into human clinical trials for the treatment of several myeloproliferative disorders.

LY2784544 (Gandotinib)

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Chemical Information

Catalog Num A10546
Actions Inhibitor
M. Wt 469.9
Formula C23H25ClFN7O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1229236-86-5
Synonyms N/A
SMILES code CC1=CC(=NN1)NC2=NN3C(=C(N=C3C(=C2)CN4CCOCC4)C)CC5=C(C=C(C=C5)Cl)F
Chemical Name 3-[(4-Chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)imidazo[1,2-b]pyridazin-6-amine

Biological Activity

Description
LY2784544 is identified as being highly selective for JAK2-V617F and has advanced into human clinical trials for the treatment of several myeloproliferative disorders.
Targets
Target Value
JAK2(V617F)ki: 0.245nM
JAK2ki: 0.288nM
JAK2IC50: 2.52nM
FLT3IC50: 4nM
JAK1IC50: 19.8nM
FLT4IC50: 25nM
FGFR2IC50: 32nM
TYK2IC50: 44nM
JAK3IC50: 48.0nM
TrkBIC50: 95nM
FGFR3IC50: 106nM
KDRIC50: 109nM
ALKIC50: 138nM
MUSKIC50: 147nM
AuroraAIC50: 168nM
MAP3K9IC50: 299nM

Solubility

Solubility (25°C)* In vitro DMSO 94 mg/mL (200.02 mM)
Water <1 mg/mL (<1 mM)
Ethanol 9 mg/mL (19.15 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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