MGCD-265

c-Met inhibitor

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Catalog No. A10587

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
MGCD-265 5mg A10587-5
$150.00
MGCD-265 10mg A10587-10
$280.00
MGCD-265 50mg A10587-50
$900.00
MGCD-265 100mg A10587-100
$1,500.00
MGCD-265 10mM * 1mL in DMSO A10587-10mM-D
$214.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

MGCD265 is a multitargeted tyrosine kinase inhibitor that binds to and inhibits the phosphorylation of several RTKs, including the c-Met receptor (HGFR); the Tek/Tie-2 receptor; VEGFR types 1, 2, and 3; and MST1R.

MGCD-265

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Chemical Information

Catalog Num A10587
Actions Inhibitor
M. Wt 517.6
Formula C26H20FN5O2S2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 875337-44-3
Synonyms MGCD265
SMILES code CN1C=C(N=C1)C2=CC3=NC=CC(=C3S2)OC4=C(C=C(C=C4)NC(=S)NC(=O)CC5=CC=CC=C5)F
Chemical Name N-(3-Fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide

Biological Activity

Description
MGCD265 is a multitargeted tyrosine kinase inhibitor that binds to and inhibits the phosphorylation of several RTKs, including the c-Met receptor (HGFR); the Tek/Tie-2 receptor; VEGFR types 1, 2, and 3; and MST1R.
Targets
Target Value
MetIC50: 1nM
RONIC50: 2nM
VEGFR1IC50: 3nM
VEGFR2IC50: 3nM
VEGFR3IC50: 4nM
Tie-2IC50: 7nM

Solubility

Solubility (25°C)* In vitro DMSO 104 mg/mL (200.92 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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