Cellular Effect
| Cell Line | Activity | Value | Description | Reference |
|---|---|---|---|---|
| MDCK | IC50 | 2.8 μM | Inhibition of MRP1 expressed in MDCK cells assessed as calcein AM accumulation after 30 mins by fluorescence assay | [PMID: 22112208] |
Fig. 1 · Structure
Documents & Downloads
Verlukast (MK-0679)
Cat. No.
A11607
CAS
120443-16-5
LTD4 receptor antagonist
Verlukast (MK-0679) is a potent leukotriene D4 antagonist
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 120443-16-5 |
| Applications | LTD4 receptor antagonist |
| Formula | C26H27ClN2O3S2 |
| Molecular Weight | 515.09 |
| Synonyms | MK-679; L 668019; MK0679 |
| SMILES | CN(C)C(=O)CCS[C@@H](C1=CC=CC(=C1)/C=C/C2=NC3=C(C=CC(=C3)Cl)C=C2)SCCC(=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.