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MK-2461

Name: MK-2461
Brand: Adooq Bioscience
SKU: A11753
Availability: InStock

Cat. No. A11753 CAS 917879-39-1

c-Met Inhibitor

MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.

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Biological Activity

Target & Activity

Target	Activity	Value
c-Met(M1250T)	IC50	0.4nM
c-Met(Y1235D)	IC50	0.5nM
c-Met(Y1230H)	IC50	1.0nM
c-Met(N1100)	IC50	1.5nM
c-Met(Y1230C)	IC50	1.5nM
c-Met	IC50	2.5nM
RON	IC50	7nM
FLT1	IC50	10nM
FLT3	IC50	22nM
PDGFRβ	IC50	22nM
Mer	IC50	24nM
FGFR2	IC50	39nM
KDR	IC50	44nM
TrkA	IC50	46nM
FGFR3	IC50	50nM
TrkB	IC50	61nM
FGFR1	IC50	65nM
FLT4	IC50	78nM
DRAK1	IC50	199nM
JAK2	IC50	225nM
IRAK4	IC50	298nM
MELK	IC50	606nM
RET	IC50	635nM
DYRK2	IC50	1.143μM
MLK1	IC50	4.303μM
IRAK1	IC50	5.459μM
Abl	IC50	7.747μM

27 targets · Scroll to view more

Cellular Effect

Cell Line	Activity	Value	Description	Reference
GTL 16 cell line	IC50	440 nM	Antiproliferative activity against human GTL16 cells after 72 hrs	[PMID: 21608528]

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	917879-39-1
Applications	c-Met Inhibitor
Formula	C₂₄H₂₅N₅O₅S
Molecular Weight	495.6
SMILES	CN1C=C(C=N1)C2=CN=C3C=CC4=C(C=C(C=C4)NS(=O)(=O)N(C)C[C@@H]5COCCO5)C(=O)C3=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

Solvent	Reported Solubility
DMSO	95 mg/mL (191.7 mM)
Water	Insoluble
Ethanol	Insoluble

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

In Vivo Preparation

Concentration: 14 mg/mL
Vehicle: 1% DMSO+30% polyethylene glycol+1% Tween 80, pH 4

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.