MK-5108 (VX-689)

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Aurora A Kinase inhibitor

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Catalog No. A11410

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
MK-5108 5mg A11410-5

Regular Price: $100.00

Special Price: $80.00

MK-5108 10mg A11410-10

Regular Price: $170.00

Special Price: $136.00

MK-5108 50mg A11410-50

Regular Price: $450.00

Special Price: $360.00

MK-5108 100mg A11410-100

Regular Price: $750.00

Special Price: $600.00

MK-5108 (VX-689) 10mM * 1mL in DMSO A11410-10mM-D

Regular Price: $120.00

Special Price: $96.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

MK-5108, also known as VX-689, is a competitive inhibitor of the ATP-binding site of aurora A kinase.

MK-5108 (VX-689)

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Chemical Information

Catalog Num A11410
Actions Inhibitor
M. Wt 461.9
Formula C22H21ClFN3O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1010085-13-8
Synonyms MK5108, VX689
SMILES code C1CC(CCC1OC2=C(C(=CC=C2)Cl)F)(CC3=NC(=CC=C3)NC4=NC=CS4)C(=O)O
Chemical Name trans-4-(3-Chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]cyclohexanecarboxylic acid

Biological Activity

Description
MK-5108, also known as VX-689, is a competitive inhibitor of the ATP-binding site of aurora A kinase.
Targets
Aurora A (Cell-free assay)
0.064 nM

Solubility

Solubility (25°C) * In vitro DMSO 92 mg/mL (199.16 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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