Search by product name, CAS, target or catalog number. Press Down Arrow to reach product suggestions, Tab to move between links, and Escape to close suggestions.
Raf inhibitor
Out of Stock
Select a size to continue
Selected package
Cat. No.
Tell us your preferred amount per vial. We’ll confirm the options.
| Target | Activity | Value |
|---|---|---|
| RAF | IC50 | 2.1 nM |
| Abl1 | IC50 | <0.5 nM |
| DDR2 | IC50 | 7.0 nM |
| KDR | IC50 | 6.2 nM |
| EPHA2 | IC50 | 11 nM |
| RET | IC50 | 0.8 nM |
6 targets · Scroll to view more
| Cell Line | Activity | Value | Description | Reference |
|---|---|---|---|---|
| A-375 | IC50 | 56 nM | Inhibition of B-Raf V600E mutant in human A375 cell line assessed as inhibition of ERK phosphorylation for 3 hrs with compound by ELISA | [PMID: 26804230] |
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1237536-18-3 |
| Applications | Raf inhibitor |
| Formula | C29H29F3N4O3.2HCl |
| Molecular Weight | 611.48 |
| SMILES | O=C(CC1)NC2=C1C(OC3=CC=C(CC[C@@H](NC(C4=CC(C(F)(F)F)=CC(C(C)(C)N)=C4)=O)C5)C5=C3)=CC=N2.Cl.Cl |
No reported solubility data are available for this product.
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
