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Fig. 1 · Structure
Cat. No.
A14647
CAS No.
62596-29-6
Formula
C25H24O6
Mol. Weight
420.45

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Morusin

Cat. No. A14647 CAS 62596-29-6
Morusin is an isoprenylated flavone.

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Biological Activity

Target & Activity

Target Activity Value
p65  
STAT3  

Cellular Effect

Cell Line Activity Value Description Reference
A549 IC50 24.09 μM Cytotoxicity against human A549 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay [PMID: 27400887]
Bcap37 IC50 33.1 μM Cytotoxicity against human Bcap37 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay [PMID: 27400887]
HEK293 IC50 59.4 μM Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay [PMID: 21511472]
HepG2 IC50 9.3 μM Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay [PMID: 27400887]
LN-18 IC50 24 μM Cytotoxicity against human LN18 cells assessed as reduction in cell viability after 24 hrs by MTT assay [PMID: 26829656]
MCF7 IC50 11.51 μM Cytotoxicity against human MCF7 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay [PMID: 27400887]
RAW264.7 IC50 > 12.5 μg/mL Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess assay [PMID: 27908762]
SR IC50 43.57 μM Inhibition of SERCA1 in NewZealand rabbit skeletal muscle SR vesicles using ATP as substrate incubated for 2 mins followed by Ca2+ addition by NADH coupled enzyme assay [PMID: 32435418]
T98G IC50 24 μM Cytotoxicity against human T98G cells assessed as reduction in cell viability after 24 hrs by MTT assay [PMID: 26829656]
U138-MG IC50 24 μM Cytotoxicity against human U138MG cells assessed as reduction in cell viability after 24 hrs by MTT assay [PMID: 26829656]
U-251 IC50 17.95 μM Cytotoxicity against human U251 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay [PMID: 27400887]
U-251 IC50 24 μM Cytotoxicity against human U251MG cells assessed as reduction in cell viability after 24 hrs by MTT assay [PMID: 26829656]
U-373MG ATCC IC50 24 μM Cytotoxicity against human U373MG cells assessed as reduction in cell viability after 24 hrs by MTT assay [PMID: 26829656]
U-87MG ATCC IC50 24 μM Cytotoxicity against human U87MG cells assessed as reduction in cell viability after 24 hrs by MTT assay [PMID: 26829656]

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Specifications

Manufacturer Adooq Bioscience
CAS Number 62596-29-6
Formula C25H24O6
Molecular Weight 420.45
SMILES
CC(=CCC1=C(OC2=C3C=CC(OC3=CC(=C2C1=O)O)(C)C)C4=C(C=C(C=C4)O)O)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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