Motesanib Diphosphate (AMG-706)

VEGFR inhibitor

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Catalog No. A10608

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Motesanib Diphosphate 5mg A10608-5

Regular Price: $30.00

Special Price: $25.50

Motesanib Diphosphate 10mg A10608-10

Regular Price: $50.00

Special Price: $42.50

Motesanib Diphosphate 50mg A10608-50

Regular Price: $160.00

Special Price: $136.00

Motesanib Diphosphate 100mg A10608-100

Regular Price: $280.00

Special Price: $238.00

Motesanib Diphosphate 10mM * 1mL in DMSO A10608-10mM-D

Regular Price: $50.00

Special Price: $42.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Motesanib, also known as AMG-706, is an orally administered multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors, and Kit receptors.

Motesanib Diphosphate (AMG-706)

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Chemical Information

Catalog Num A10608
Actions Inhibitor
M. Wt 569.4
Formula C22H23N5O.2H3PO4
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 857876-30-3
Synonyms AMG-706
SMILES code CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C.OP(=O)(O)O.OP(=O)(O)O
Chemical Name N-(2,3-Dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide diphosphate

Biological Activity

Description
Motesanib, also known as AMG-706, is an orally administered multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors, and Kit receptors.
Targets
Target Value
VEGFR1IC50: 2nM
VEGFR2IC50: 3nM
VEGFR2/Flk1IC50: 6nM
VEGFR3IC50: 6nM
KitIC50: 8nM
RETIC50: 59nM
PDGFRIC50: 84nM
FGFRIC50: >2.8μM
EGFRIC50: >3μM
SrcIC50: >3μM
p38IC50: >3μM

Solubility

Solubility (25°C) * In vitro DMSO 100 mg/mL heating (175.61 mM)
Water 19 mg/mL heating (33.36 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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