NMS-1286937

PLK inhibitor

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Catalog No. A13045

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
NMS-1286937 10mg A13045-10
$120.00
NMS-1286937 25mg A13045-25
$250.00
NMS-1286937 50mg A13045-50
$400.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

NMS-1286937 is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity.

NMS-1286937

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Chemical Information

Catalog Num A13045
Actions Inhibitor
M. Wt 532.52
Formula C24H27F3N8O3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1034616-18-6
Synonyms NMS1286937, NMS-P937
SMILES code CN1CCN(CC1)C2=CC(=C(C=C2)OC(F)(F)F)NC3=NC=C4CCC5=C(C4=N3)N(N=C5C(=O)N)CCO
Chemical Name 4,5-dihydro-1-(2-hydroxyethyl)-8-[[5-(4-methyl-1-piperazinyl)-2-(trifluoromethoxy)phenyl]amino]-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

Biological Activity

Description
NMS-1286937 is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity.
Targets
PLK1 PLK2 PLK3
2 nM>10 μM>10 μM

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