Fig. 1 · Structure

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Nuciferine

Cat. No. A14505 CAS 475-83-2
Nuciferine is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera.

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Biological Activity

Target & Activity

Target Activity Value
5-HT2C Receptor IC50 131 nM
5-HT7 Receptor IC50 150 nM
5-HT2A Receptor IC50 478 nM
5-HT2B Receptor IC50 1 μM
5-HT6 Receptor EC50 700 nM
5-HT1A Receptor EC50 3.2 μM
D2 Receptor EC50 64 nM
D4 Receptor EC50 2 μM
D5 Receptor EC50 2.6 μM

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Cellular Effect

Cell Line Activity Value Description Reference
B16-4A5 IC50 15.8 μM Inhibition of melanogenesis in mouse B16-4A5 cells after 72 hrs by spectrophotometry [PMID: 23270663]

Specifications

Manufacturer Adooq Bioscience
CAS Number 475-83-2
Formula C19H21NO2
Molecular Weight 295.38
SMILES
CN1CCC2=CC(=C(C3=C2C1CC4=CC=CC=C43)OC)OC

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 2 mg/mL (6.77 mM)
Water Insoluble
Ethanol Insoluble

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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