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Nutlin 3b

Name: Nutlin 3b
Brand: Adooq Bioscience
SKU: A11502
Availability: InStock

Cat. No. A11502 CAS 675576-97-3

MDM2 inhibitor

Nutlin 3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 uM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.

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Biological Activity

Target & Activity

Target	Activity	Value
Mdm2		13.6 μM

Cellular Effect

Cell Line	Activity	Value	Description	Reference
A549	IC50	10 μM	Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay	[PMID: 28797774]
A549	IC50	2.4 μM	Antiproliferative activity against human A549 cells measured after 24 hrs by CCK8 assay	[PMID: 31047751]
HCT-116	GI50	1.52 μM	Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 3 days by SRB assay	[PMID: 28743509]
HCT-116	IC50	28.4 μM	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay	[PMID: 28797774]
HCT-116	IC50	4 μM	Antiproliferative activity against human HCT116 cells measured after 24 hrs by CCK8 assay	[PMID: 31047751]
MCF7	IC50	12.1 μM	Antiproliferative activity against human MCF7 cells measured after 24 hrs by CCK8 assay	[PMID: 31047751]
MCF7	IC50	14.9 μM	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay	[PMID: 28797774]
SAOS-2	IC50	20.16 μM	Cytotoxicity against p53 deficient human Saos2 cells assessed as cell growth inhibition after 24 hrs by MTT assay	[PMID: 28482147]
U2OS	IC50	2.66 μM	Cytotoxicity against wild type p53 expressing human U2OS cells assessed as cell growth inhibition after 24 hrs by MTT assay	[PMID: 28482147]
U-87MG ATCC	IC50	5.93 μM	Cytotoxicity against human U87 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 28916339]

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor, Antagonist
CAS Number	675576-97-3
Applications	MDM2 inhibitor
Formula	C₃₀H₃₀Cl₂N₄O₄
Molecular Weight	581.49
Synonyms	(+)-Nutlin-3
SMILES	CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@@H]([C@@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

Solvent	Reported Solubility
DMSO	90 mg/mL (154.77 mM)
Water	Insoluble
Ethanol	90 mg/mL (154.77 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.