Fig. 1 · Structure

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NVP-LCQ195

Cat. No. A15196 CAS 902156-99-4

CDK inhibitor

NVP-LCQ195 is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM.

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Biological Activity

Target & Activity

Target Activity Value
Cdk5/p25 IC50 1 nM
CDK5/p35 IC50 1 nM
Cdk1/cyclin B IC50 2 nM
cdk2/cyclin A IC50 2 nM
CDK2/cyclinE IC50 5 nM
CDK9/cyclinT1 IC50 15 nM
CDK3/Cyclin E IC50 42 nM
cdk6/cyclin D3 IC50 187 nM
CDK7/Cyclin H/MAT1 IC50 3564 nM

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 902156-99-4
Applications CDK inhibitor
Formula C17H19Cl2N5O4S
Molecular Weight 460.33
Synonyms LCQ-195; AT-9311
SMILES
CS(=O)(=O)N1CCC(CC1)NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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