NVP-TAE 226

ON SALE

FAK inhibitor

0 Customer Reviews
Catalog No. A11507

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
NVP-TAE 226 5mg A11507-5

Regular Price: $100.00

Special Price: $85.00

NVP-TAE 226 10mg A11507-10

Regular Price: $180.00

Special Price: $153.00

NVP-TAE 226 25mg A11507-25

Regular Price: $320.00

Special Price: $272.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

NVP-TAE226 is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2(IC50=3.5 nM); 10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met.

NVP-TAE 226

Double click on above image to view full picture

Zoom Out
Zoom In

More Views

Publications citing Adooq Products

Chemical Information

Catalog Num A11507
Actions Inhibitor
M. Wt 468.94
Formula C23H25ClN6O3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 761437-28-9
Synonyms TAE226, TAE 226
SMILES code CNC(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCOCC4)OC
Chemical Name 2-[[5-chloro-2-(2-methoxy-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]-N-methylbenzamide

Biological Activity

Description
NVP-TAE226 is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2(IC50=3.5 nM); 10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met.
Targets
Target Value
PYK2IC50: 3.5nM
FAKIC50: 5.5nM
Insulin ReceptorIC50: 43.5nM
IGF-1RIC50: 140nM
c-MetIC50: 160nM
FLT4IC50: 220nM
KDRIC50: 360nM
FLT3IC50: 480nM
CDK1/CyclinBIC50: 540nM
TekIC50: 580nM
FGFR3(K650E)IC50: 630nM
FGFR1IC50: 750nM
JAK2IC50: 840nM
c-SrcIC50: 905nM
HER2IC50: 945nM
RETIC50: 1.3μM
HER1IC50: 1.7μM
RET(M918T)IC50: 2.3μM
PDK-1IC50: 2.4μM
PDGFRβIC50: 2.6μM
FLT1IC50: 3.4μM
c-AblIC50: 5.85μM
ZAP70IC50: 7.7μM
SykIC50: 7.9μM
PKAIC50: >10μM
PKBIC50: >10μM
C-RafIC50: >10μM

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.


Keywords:buy NVP-TAE 226 | NVP-TAE 226 Supplier | purchase NVP-TAE 226 | NVP-TAE 226 cost | NVP-TAE 226 manufacturer | order NVP-TAE 226 | NVP-TAE 226 distributor | buy 761437-28-9| 761437-28-9 Supplier | purchase 761437-28-9 | 761437-28-9 cost | 761437-28-9 manufacturer | order 761437-28-9 | 761437-28-9 distributor