NVP-TAE 226

Catalog No.: A11507
FAK inhibitor
NVP-TAE226 is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2(IC50=3.5 nM); 10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met.
Grouped product items
Product Name Price Stock Qty
NVP-TAE 226 5mg
$100.00
In stock
NVP-TAE 226 10mg
$180.00
In stock
NVP-TAE 226 25mg
$320.00
In stock
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Adooq Products cited in reputable paper
Adooq's NVP-TAE 226 has been cited by 1 publications
  • Vijaya Bharti, .et al. , Cell Rep, 2022, Dec 20;41(12):111826 PMID: 36543138
  • Biological Activity
    Discription NVP-TAE226 is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2(IC50=3.5 nM); 10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met.
    Targets
    Target Value
    Product Information
    Catalog Num A11507
    Formula C23H25ClN6O3
    Molecular Weight 468.94
    CAS Number 761437-28-9
    SMILES CNC(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCOCC4)OC
    Synonyms TAE226, TAE 226
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 93 mg/mL (198.32 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 0.5% methylcellulose 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 21.32 mL 106.62 mL 213.25 mL
    0.5 mM 4.26 mL 21.32 mL 42.65 mL
    1 mM 2.13 mL 10.66 mL 21.32 mL
    5 mM 0.43 mL 2.13 mL 4.26 mL
    Useful Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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