OSI-027

mTOR inhibitor

0 Customer Reviews
Catalog No. A11056

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
OSI-027 5mg A11056-5
$70.00
OSI-027 10mg A11056-10
$120.00
OSI-027 50mg A11056-50
$350.00
OSI-027 100mg A11056-100
$600.00
OSI-027 10mM * 1mL in DMSO A11056-10mM-D
$116.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

OSI-027 is a potent, selective and orally bioavailable mTOR kinase inhibitor that inhibits the kinase activity associated with both the TORC1 and TORC2 complexes of mTOR.

OSI-027

Double click on above image to view full picture

Zoom Out
Zoom In

More Views

Publications citing Adooq Products

Chemical Information

Catalog Num A11056
Actions Inhibitor
M. Wt 406.4
Formula C21H22N6O3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 936890-98-1
Synonyms OSI027
SMILES code COC1=CC=CC2=C/C(=C/3\C4=C(N=CNN4C(=N3)C5CCC(CC5)C(=O)O)N)/N=C21
Chemical Name 4-(4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid hydrochloride

Biological Activity

Description
OSI-027 is a potent, selective and orally bioavailable mTOR kinase inhibitor that inhibits the kinase activity associated with both the TORC1 and TORC2 complexes of mTOR.
Targets
Target Value
mTORIC50: 4nM
mTORC1IC50: 22nM
mTORC2IC50: 65nM
PI3KγIC50: 0.42μM
DNA-PKIC50: 1.0μM
PI3KαIC50: 1.3μM
C-RafIC50: 1.6μM
YES1IC50: 2.8μM
EphA2IC50: 4.5μM
BTKIC50: 5.0μM
LCKIC50: 9.5μM
ACK1IC50: >10μM
p38αIC50: 10.6μM
KDRIC50: 19.0μM
PI3KβIC50: >30μM
IGF-1RIC50: >30μM
Insulin ReceptorIC50: >30μM
PDK-1IC50: >30μM
PKAIC50: >30μM
EGFR/ErbB1IC50: >30μM
MST1RIC50: >30μM
SrcIC50: >30μM
MEK1IC50: >30μM
FynIC50: >30μM

Solubility

Solubility (25°C) * In vitro DMSO 18 mg/mL (44.28 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.


Keywords:buy OSI-027 | OSI-027 Supplier | purchase OSI-027 | OSI-027 cost | OSI-027 manufacturer | order OSI-027 | OSI-027 distributor | buy 936890-98-1| 936890-98-1 Supplier | purchase 936890-98-1 | 936890-98-1 cost | 936890-98-1 manufacturer | order 936890-98-1 | 936890-98-1 distributor