OSI-930

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c-Kit/VEGFR Inhibitor

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Catalog No. A10679

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
OSI-930 5mg A10679-5

Regular Price: $90.00

Special Price: $72.00

OSI-930 25mg A10679-25

Regular Price: $200.00

Special Price: $160.00

OSI-930 50mg A10679-50

Regular Price: $350.00

Special Price: $280.00

OSI-930 100mg A10679-100

Regular Price: $600.00

Special Price: $480.00

OSI-930 10mM * 1mL in DMSO A10679-10mM-D

Regular Price: $139.00

Special Price: $111.20

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

OSI-930 is a potent inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively.

OSI-930

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Chemical Information

Catalog Num A10679
Actions Inhibitor
M. Wt 443.4
Formula C22H16F3N3O2S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 728033-96-3
Synonyms OSI930
SMILES code C1=CC=C2C(=C1)C(=CC=N2)CNC3=C(SC=C3)C(=O)NC4=CC=C(C=C4)OC(F)(F)F
Chemical Name 3-[(4-Quinolinylmethyl)amino]-N-[4-(trifluoromethoxy)phenyl]-2-thiophenecarboxamide

Biological Activity

Description
OSI-930 is a potent inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively.
Targets
Target Value
FLT1IC50: 8nM
KDRIC50: 9nM
CSF-1RIC50: 15nM
LCKIC50: 22nM
C-RafIC50: 41nM
KitIC50: 80nM
FLT3IC50: 1.303μM
PDGFRαIC50: 3.408μM
AblIC50: 4.738μM
PDGFRβIC50: 6.9μM
EGFRIC50: >10μM
AuroraAIC50: >10μM
AxlIC50: >10μM
CDK2/CyclinAIC50: >10μM
IKKβIC50: >10μM
MEK1IC50: >10μM
PDPK1IC50: >10μM
PKBβIC50: >10μM
Tie-2IC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 89 mg/mL (200.7 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (6.76 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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