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Fig. 1 · Structure
Cat. No.
A15201
CAS No.
939981-37-0
Formula
C40H49Cl2N5O4
Mol. Weight
734.75

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p53 and MDM2 proteins-interaction-inhibitor chiral

Cat. No. A15201 CAS 939981-37-0

p53-MDM2 interaction inhibitor

p53 and MDM2 proteins-interaction-inhibitor chiral is an inhibitor of the interaction between p53 and MDM2 proteins.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
HCT-116 IC50 0.6 μM Cytotoxicity against human HCT116 cells expressing wild type p53 assessed as cell viability after 5 days by MTT assay [PMID: 24900694]
MDA-MB-435 IC50 17.5 μM Cytotoxicity against human MDA-MB-435 cells expressing p53 mutant assessed as cell viability after 5 days by MTT assay [PMID: 24900694]
RKO IC50 0.6 μM Cytotoxicity against human RKO cells expressing wild type p53 assessed as cell viability after 5 days by MTT assay [PMID: 24900694]
SJSA-1 IC50 0.2 μM Cytotoxicity against human SJSA1 cells expressing wild type p53 assessed as cell viability after 5 days by MTT assay [PMID: 24900694]
SW480 IC50 14.4 μM Cytotoxicity against human SW480 cells expressing p53 mutant assessed as cell viability after 5 days by MTT assay [PMID: 24900694]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 939981-37-0
Applications p53-MDM2 interaction inhibitor
Formula C40H49Cl2N5O4
Molecular Weight 734.75
SMILES
CCOC1=C(C=CC(=C1)C(C)(C)C)C2=N[C@@]([C@@](N2C(=O)N3CCN(CC3)CC(=O)N4CCOCC4)(C)C5=CC=C(C=C5)Cl)(C)C6=CC=C(C=C6)Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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