Pazopanib HCl (GW786034)

Catalog No.: A10699
VEGFR/PDGFR/FGFR inhibitor
Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.
Grouped product items
Product Name Price Stock Qty
Pazopanib Hydrochloride 10mg
$40.00
In stock
Pazopanib Hydrochloride 25mg
$60.00
In stock
Pazopanib Hydrochloride 50mg
$100.00
In stock
Pazopanib Hydrochloride 100mg
$150.00
In stock
Pazopanib HCl (GW786034) 10mM * 1mL in DMSO
$50.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's Pazopanib HCl (GW786034) has been cited by 4 publications
  • Aya Hasan Alshammari, .et al. , Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
  • Majid Momeny, .et al. , Life Sci, 2021, Dec 15;287:120100 PMID: 34715143
  • Hideharu Yamada, .et al. , Oncol Lett, 2021, Jun;21(6):455 PMID: 33907565
  • Majid Momeny, .et al. , Eur J Pharmacol, 2020, 882:173298
  • Biological Activity
    Discription Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.
    Targets
    Target Value
    Product Information
    Catalog Num A10699
    Formula C21H23N7O2S.HCl
    Molecular Weight 474
    CAS Number 635702-64-6
    SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N.Cl
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 15 mg/mL (31.64 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 21.1 mL 105.49 mL 210.97 mL
    0.5 mM 4.22 mL 21.1 mL 42.19 mL
    1 mM 2.11 mL 10.55 mL 21.1 mL
    5 mM 0.42 mL 2.11 mL 4.22 mL
    Useful Calculator

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    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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