PCI-34051

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HDAC inhibitor

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Catalog No. A11152

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PCI-34051 10mg A11152-10

Regular Price: $100.00

Special Price: $80.00

PCI-34051 25mg A11152-25

Regular Price: $200.00

Special Price: $160.00

PCI-34051 50mg A11152-50

Regular Price: $350.00

Special Price: $280.00

PCI-34051 100mg A11152-100

Regular Price: $660.00

Special Price: $528.00

PCI-34051 10mM * 1mL in DMSO A11152-10mM-D

Regular Price: $60.00

Special Price: $48.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PCI-34051 is a specific and potent histone deacetylase 8 (HDAC8) inhibitor, with >200-fold selectivity over the other HDAC isoforms.

PCI-34051

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Chemical Information

Catalog Num A11152
Actions Inhibitor
M. Wt 296.3
Formula C17H16N2O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 950762-95-5
Synonyms PCI34051
SMILES code COC1=CC=C(C=C1)CN2C=CC3=C2C=C(C=C3)C(=O)NO
Chemical Name N-Hydroxy-1-(4-methoxybenzyl)-1H-indole-6-carboxamide

Biological Activity

Description
PCI-34051 is a specific and potent histone deacetylase 8 (HDAC8) inhibitor, with >200-fold selectivity over the other HDAC isoforms.
Targets
Target Value
HDAC8IC50: 10nM
HDAC6IC50: 2.9μM
HDAC1IC50: 4μM
HDAC10IC50: 13μM
HDAC2IC50: >50μM
HDAC3IC50: >50μM

Solubility

Solubility (25°C) * In vitro DMSO 59 mg/mL (199.1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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