PF 4708671

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S6 kinase inhibitor

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Catalog No. A11755

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PF 4708671 10mg A11755-10

Regular Price: $60.00

Special Price: $51.00

PF 4708671 25mg A11755-25

Regular Price: $120.00

Special Price: $102.00

PF 4708671 50mg A11755-50

Regular Price: $200.00

Special Price: $170.00

PF 4708671 100mg A11755-100

Regular Price: $350.00

Special Price: $297.50

PF 4708671 10mM * 1mL in DMSO A11755-10mM-D

Regular Price: $82.00

Special Price: $69.70

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PF 4708671 is a highly specific inhibitor of p70 ribosomal S6 kinase (S6K1) that inhibits S6K1-mediated phosphorylation of S6 protein in response to IGF-1 , while having no effect on highly related RSK and MSK kinases.

PF 4708671

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Chemical Information

Catalog Num A11755
Actions Inhibitor
M. Wt 390.4
Formula C19H21F3N6
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1255517-76-0
Synonyms PF4708671, PF-4708671
SMILES code CCC1=CN=CN=C1N2CCN(CC2)CC3=NC4=C(N3)C=C(C=C4)C(F)(F)F
Chemical Name 2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]imidazole

Biological Activity

Description
PF 4708671 is a highly specific inhibitor of p70 ribosomal S6 kinase (S6K1) that inhibits S6K1-mediated phosphorylation of S6 protein in response to IGF-1 , while having no effect on highly related RSK and MSK kinases.
Targets
p70 S6K1 (Cell-free assay)
160 nM

Solubility

Solubility (25°C) * In vitro DMSO 30 mg/mL (76.84 mM)
Water <1 mg/mL (<1 mM)
Ethanol 8 mg/mL (20.49 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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