Target & Activity
| Target | Activity | Value |
|---|---|---|
| Chk1 (Cell-free assay) | Ki | 0.49 nM |
| VEGFR2 (Cell-free assay) | Ki | 8 nM |
| Fms (Cell-free assay) | Ki | 10 nM |
| YES (Cell-free assay) | Ki | 14 nM |
| Chk2 (Cell-free assay) | Ki | 47 nM |
Fig. 1 · Structure
Documents & Downloads
PF 477736
Cat. No.
A11520
CAS
952021-60-2
Chk Inhibitor
PF 477736 is a selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively).
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 952021-60-2 |
| Applications | Chk Inhibitor |
| Formula | C22H25N7O2 |
| Molecular Weight | 419.48 |
| Synonyms | PF-0044736 |
| SMILES | CN1C=C(C=N1)C2=NC3=C4C2=CNNC(=O)C4=CC(=C3)NC(=O)[C@@H](C5CCCCC5)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 5 mg/mL (11.92 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
In Vivo Preparation
- Concentration
- 4 mg/mL
- Vehicle
- 2% DMSO+40% PEG 300
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.