PF 477736

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Chk Inhibitor

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Catalog No. A11520

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PF 477736 5mg A11520-5

Regular Price: $90.00

Special Price: $76.50

PF 477736 10mg A11520-10

Regular Price: $140.00

Special Price: $119.00

PF 477736 25mg A11520-25

Regular Price: $280.00

Special Price: $238.00

PF 477736 50mg A11520-50

Regular Price: $450.00

Special Price: $382.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PF 477736 is a selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively).

PF 477736

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Chemical Information

Catalog Num A11520
Actions Inhibitor
M. Wt 419.48
Formula C22H25N7O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 952021-60-2
Synonyms PF-0044736, PF0044736
SMILES code CN1C=C(C=N1)C2=NC3=C4C2=CNNC(=O)C4=CC(=C3)NC(=O)[C@@H](C5CCCCC5)N
Chemical Name N/A

Biological Activity

Description
PF 477736 is a selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively).
Targets
Chk1 (Cell-free assay) VEGFR2 (Cell-free assay) Fms (Cell-free assay) YES (Cell-free assay) Chk2 (Cell-free assay)
0.49 nM(Ki)8 nM(Ki)10 nM(Ki)14 nM(Ki)47 nM(Ki)

Solubility

Solubility (25°C) * In vitro DMSO 6 mg/mL (14.3 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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