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Fig. 1 · Structure
Cat. No.
A13039
CAS No.
1415562-82-1
Formula
C27H31NO4S
Mol. Weight
465.6

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PF-543

Cat. No. A13039 CAS 1415562-82-1

SphK1 inhibitor

PF-543 is a novel selective SK-1 inhibitor which inhibited SK-1 activity in a competitive manner with sphingosine.

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Biological Activity

Target & Activity

Target Activity Value
SphK1 2.0 nM
SphK1 Ki 3.6 nM

Cellular Effect

Cell Line Activity Value Description Reference
HEK293 IC50 28 nM Inhibition of GFP-tagged SK1 (unknown origin) expressed in HEK293 cells using Sph as substrate measured after 30 mins in presence of [gamma32P]ATP by Cerenkov counting analysis [PMID: 30889352]
HT-29 IC50 13.02 μM Antiproliferative activity against human HT-29 cells incubated for 72 hrs by SRB assay [PMID: 35439002]
MDA-MB-231 IC50 27.12 μM Antiproliferative activity against human MDA-MB-231 cells for 72 hrs by SRB assay [PMID: 35439002]
PC-3 GI50 19 μM Antiproliferative activity against human PC3 cells after 72 hrs by MTS assay [PMID: 26780304]
Sf9 IC50 > 5000 nM Inhibition of recombinant human full-length N-terminal His-tagged SK2 expressed in baculovirus infected Sf9 insect cells using Sph as substrate measured after 30 mins in presence of [gamma32P]ATP by Cerenkov counting analysis [PMID: 30889352]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 1415562-82-1
Applications SphK1 inhibitor
Formula C27H31NO4S
Molecular Weight 465.6
SMILES
CC1=CC(=CC(=C1)OCC2=CC=C(C=C2)CN3CCC[C@@H]3CO)CS(=O)(=O)C4=CC=CC=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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