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SphK1 inhibitor

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Catalog No. A13039

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PF-543 10mg A13039-10

Regular Price: $150.00

Special Price: $120.00

PF-543 25mg A13039-25

Regular Price: $300.00

Special Price: $240.00

PF-543 50mg A13039-50

Regular Price: $500.00

Special Price: $400.00

PF-543 10mM * 1mL in DMSO A13039-10mM-D

Regular Price: $129.00

Special Price: $103.20

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PF-543 is a novel selective SK-1 inhibitor which inhibited SK-1 activity in a competitive manner with sphingosine.


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Chemical Information

Catalog Num A13039
Actions Inhibitor
M. Wt 465.6
Formula C27H31NO4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1415562-82-1
Synonyms PF543,PF 543
SMILES code CC1=CC(=CC(=C1)OCC2=CC=C(C=C2)CN3CCC[[email protected]@H]3CO)CS(=O)(=O)C4=CC=CC=C4
Chemical Name (R)-(1-(4-((3-methyl-5-((phenylsulfonyl)methyl)phenoxy)methyl)benzyl)pyrrolidin-2-yl)methanol

Biological Activity

PF-543 is a novel selective SK-1 inhibitor which inhibited SK-1 activity in a competitive manner with sphingosine.
SphK1 SphK1
2.0 nM3.6 nM(Ki)


Solubility (25°C)* In vitro DMSO 93 mg/mL (199.74 mM)
Water <1 mg/mL (<1 mM)
Ethanol 93 mg/mL (199.74 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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