PHA-665752

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c-Met Inhibitor

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Catalog No. A10713

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PHA-665752 5mg A10713-5

Regular Price: $50.00

Special Price: $42.50

PHA-665752 10mg A10713-10

Regular Price: $80.00

Special Price: $68.00

PHA-665752 50mg A10713-50

Regular Price: $300.00

Special Price: $255.00

PHA-665752 100mg A10713-100

Regular Price: $560.00

Special Price: $476.00

PHA-665752 10mM * 1mL in DMSO A10713-10mM-D

Regular Price: $90.00

Special Price: $76.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PHA665752 is a small-molecule inhibitor of c-Met/HGF/SF signaling.

PHA-665752

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Chemical Information

Catalog Num A10713
Actions Inhibitor
M. Wt 641.6
Formula C32H34Cl2N4O4S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 477575-56-7
Synonyms PHA665752
SMILES code CC1=C(NC(=C1C(=O)N2CCC[C@@H]2CN3CCCC3)C)/C=C\4/C5=C(C=CC(=C5)S(=O)(=O)CC6=C(C=CC=C6Cl)Cl)NC4=O
Chemical Name (2R)-1-[[5-[(Z)-[5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine

Biological Activity

Description
PHA665752 is a small-molecule inhibitor of c-Met/HGF/SF signaling.
Targets
Target Value
c-MetIC50: 9nM
RONIC50: 68nM
Flk1IC50: 200nM
c-AblIC50: 1.4μM
FGFR1IC50: 3μM
EGFRIC50: 3.8μM
c-SrcIC50: 6μM
IGF-1RIC50: >10μM
PDGFRIC50: >10μM
AuroraA2IC50: >10μM
PKAIC50: >10μM
PKBαIC50: >10μM
CDK2IC50: >10μM
p38αIC50: >10μM
MK2IC50: >10μM
MK3IC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 128 mg/mL (199.49 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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