PHA-680632

Catalog No.: A10714
Aurora inhibitor
PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.
Grouped product items
Product Name Price Stock Qty
PHA-680632 5mg
$90.00
In stock
PHA-680632 10mg
$160.00
In stock
PHA-680632 50mg
$450.00
In stock
PHA-680632 100mg
$750.00
In stock
PHA-680632 10mM * 1mL in DMSO
$149.00
In stock
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Biological Activity
Discription PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.
Targets
Target Value
Product Information
Catalog Num A10714
Formula C28H35N7O2
Molecular Weight 501.6
CAS Number 398493-79-3
SMILES CCC1=C(C(=CC=C1)CC)NC(=O)N2CC3=C(C2)NN=C3NC(=O)C4=CC=C(C=C4)N5CCN(CC5)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 91 mg/mL (181.41 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+50% PEG 300+5% Tween 80+ddH2O 14 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.94 mL 99.68 mL 199.36 mL
0.5 mM 3.99 mL 19.94 mL 39.87 mL
1 mM 1.99 mL 9.97 mL 19.94 mL
5 mM 0.4 mL 1.99 mL 3.99 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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