PHA-680632 ON SALE Aurora inhibitor

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Catalog No. A10714

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PHA-680632 5mg A10714-5

Regular Price: $90.00

Special Price: $76.50

PHA-680632 10mg A10714-10

Regular Price: $160.00

Special Price: $136.00

PHA-680632 50mg A10714-50

Regular Price: $450.00

Special Price: $382.50

PHA-680632 100mg A10714-100

Regular Price: $750.00

Special Price: $637.50

PHA-680632 10mM * 1mL in DMSO A10714-10mM-D

Regular Price: $149.00

Special Price: $126.65

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PHA-680632 is the first representative of a new class of Aurora inhibitors with a high potential for further development as an anticancer therapeutic.

PHA-680632

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Chemical Information

Catalog Num A10714
Actions Inhibitor
M. Wt 501.6
Formula C28H35N7O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 398493-79-3
Synonyms PHA680632
SMILES code CCC1=C(C(=CC=C1)CC)NC(=O)N2CC3=C(C2)NN=C3NC(=O)C4=CC=C(C=C4)N5CCN(CC5)C
Chemical Name N-(2,6-diethylphenyl)-3-(4-(4-methylpiperazin-1-yl)benzamido)pyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxamide

Biological Activity

Description
PHA-680632 is the first representative of a new class of Aurora inhibitors with a high potential for further development as an anticancer therapeutic.
Targets
Target Value
AuroraAIC50: 27nM
AuroraCIC50: 120nM
AuroraBIC50: 135nM
FGFR1IC50: 390nM
PLK1IC50: 780nM
FLT3IC50: 820nM
VEGFR3IC50: 1000nM
VEGFR2IC50: 1920nM
LCKIC50: 1950nM
STLK2IC50: 5500nM

Solubility

Solubility (25°C) * In vitro DMSO 100 mg/mL (199.35 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 10% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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