PHA-848125 (Milciclib)

Catalog No.: A11047
CDK Inhibitor
PHA-848125 (Milciclib) is an orally bioavailable inhibitor of CDKs and TRKA with potential antineoplastic activity.
Grouped product items
Product Name Stock
PHA-848125 5mg
PHA-848125 10mg
PHA-848125 50mg
PHA-848125 100mg
PHA-848125 (Milciclib) 10mM * 1mL in DMSO
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Biological Activity
Discription PHA-848125 (Milciclib) is an orally bioavailable inhibitor of CDKs and TRKA with potential antineoplastic activity.
Targets
Target Value
Product Information
Catalog Num A11047
Formula C25H32N8O
Molecular Weight 460.6
CAS Number 802539-81-7
SMILES CC1(CC2=CN=C(N=C2C3=C1C(=NN3C)C(=O)NC)NC4=CC=C(C=C4)N5CCN(CC5)C)C
Synonyms Milciclib, PHA848125
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 91 mg/mL (197.58 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.71 mL 108.55 mL 217.11 mL
0.5 mM 4.34 mL 21.71 mL 43.42 mL
1 mM 2.17 mL 10.86 mL 21.71 mL
5 mM 0.43 mL 2.17 mL 4.34 mL
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