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Piperlongumine

TrxR1/CRM1 inhibitor

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Catalog No. A14124

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Piperlongumine 25mg A14124-25

Regular Price: $90.00

Special Price: $72.00

Piperlongumine 50mg A14124-50

Regular Price: $150.00

Special Price: $120.00

Piperlongumine 10mM * 1mL in DMSO A14124-10mM-D

Regular Price: $60.00

Special Price: $48.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Piperlongumine selectively kills cancer cells regardless of p53 status without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1).

Piperlongumine

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Chemical Information

Catalog Num A14124
Actions Inducer
M. Wt 317.3
Formula C17H19NO5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 20069-09-4
Synonyms Piplartine
SMILES code COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCC=CC2=O
Chemical Name 5,?6-?dihydro-?1-?[(2E)-?1-?oxo-?3-?(3,?4,?5-?trimethoxyphenyl)-?2-?propen-?1-?yl]-?2(1H)-?pyridinone

Biological Activity

Description
Piperlongumine selectively kills cancer cells regardless of p53 status without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1).
Targets
reactive oxygen species (ROS)

Solubility

Solubility (25°C)* In vitro DMSO 16 mg/mL heating (50.41 mM)
Water <1 mg/mL (<1 mM)
Ethanol 6 mg/mL heating (18.9 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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