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PRX-08066

Name: PRX-08066
Brand: Adooq Bioscience
SKU: A13267
Availability: InStock

Cat. No. A13267 CAS 866206-54-4

5-HT2B receptor antagonist

PRX-08066, a Novel 5-Hydroxytryptamine Receptor 2B Antagonist, reduced monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats.

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Biological Activity

Target & Activity

Target	Activity	Value
5-HT2B Receptor	IC50	3.4 nM

Cellular Effect

Cell Line	Activity	Value	Description	Reference
CHO-K1	IC50	270 nM	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	[PMID: 19307114]
CHO-K1	IC50	3.5 nM	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	[PMID: 19307114]

Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	866206-54-4
Applications	5-HT2B receptor antagonist
Formula	C₁₉H₁₇ClFN₅S
Molecular Weight	401.89
SMILES	C1CN(CCC1NC2=C3C=C(SC3=NC=N2)Cl)CC4=CC(=C(C=C4)F)C#N

Storage & Solubility

In Vitro Solubility

Reported Solubility

Solvent	Reported Solubility
DMSO	92 mg/mL (177.61 mM)
Water	92 mg/mL (177.61 mM)
Ethanol	86 mg/mL (166.03 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.