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HCV Nucleotide Inhibitor

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Catalog No. A11529

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PSI-7977 5mg A11529-5

Regular Price: $60.00

Special Price: $54.00

PSI-7977 10mg A11529-10

Regular Price: $90.00

Special Price: $81.00

PSI-7977 25mg A11529-25

Regular Price: $120.00

Special Price: $108.00

PSI-7977 10mM * 1mL in DMSO A11529-10mM-D

Regular Price: $80.00

Special Price: $72.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM).


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Chemical Information

Catalog Num A11529
Actions Inhibitor
M. Wt 529.45
Formula C22H29FN3O9P
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1190307-88-0
Synonyms Sofosbuvir, PSI7977, GI-7977
SMILES code C[[email protected]@H](C(=O)OC(C)C)N[[email protected]](=O)(OC[[email protected]@H]1[[email protected]]([[email protected]@]([[email protected]@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3
Chemical Name N-[[P(S),2'R]-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester

Biological Activity

PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM).
NS5B polymerase


Solubility (25°C)* In vitro DMSO 100 mg/mL heating (188.87 mM)
Water 11 mg/mL heating (20.77 mM)
Ethanol 100 mg/mL (188.87 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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