RI-1

RAD51 Inhibitor II

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Catalog No. A13187

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
RI-1 5mg A13187-5
$90.00
RI-1 10mg A13187-10
$150.00
RI-1 25mg A13187-25
$300.00
RI-1 50mg A13187-50
$500.00
RI-1 10mM * 1mL in DMSO A13187-10mM-D
$124.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

RI-1 is a small molecule that inhibits the central recombination protein RAD51. RI-1 specifically reduces gene conversion in human cells while stimulating single strand annealing. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319 that likely destabilizes an interface used by RAD51 monomers to oligomerize into filaments on DNA.

RI-1

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Chemical Information

Catalog Num A13187
Actions Inhibitor
M. Wt 361.61
Formula C14H11Cl3N2O3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 415713-60-9
Synonyms RI1?? RI 1
SMILES code C1COCCN1C2=C(C(=O)N(C2=O)C3=CC(=C(C=C3)Cl)Cl)Cl
Chemical Name 3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione

Biological Activity

Description
RI-1 is a small molecule that inhibits the central recombination protein RAD51. RI-1 specifically reduces gene conversion in human cells while stimulating single strand annealing. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319 that likely destabilizes an interface used by RAD51 monomers to oligomerize into filaments on DNA.
Targets
RAD51
<30 μM

Solubility

Solubility (25°C)* In vitro DMSO 50 mg/mL (138.27 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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