Fig. 1 · Structure

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RO-9187

Cat. No. A15224 CAS 876708-03-1

HCV replication inhibitor

RO-9187 is a potent inhibitor of HCV virus replication in the replicon system (IC(50) = 171 +/- 12 nM; CC(50) >1 mM).

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
HeLa CC50 > 100 μM Cytotoxicity against human HeLa cells assessed as cell viability by CellTiter-Glo luminescent assay [PMID: 25667954]
HeLa EC50 0.52 μM Antiviral activity against Respiratory syncytial virus subgenomic replicon system in 395 HeLa cells assessed as reduction in viral replication after 7 days by renilla luciferase assay [PMID: 25667954]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 876708-03-1
Applications HCV replication inhibitor
Formula C9H12N6O5
Molecular Weight 284.23
SMILES
C1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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