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Fig. 1 · Structure
Cat. No.
A11553
CAS No.
99755-59-6
Formula
C19H25NOS
Mol. Weight
315.47

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Rotigotine

Cat. No. A11553 CAS 99755-59-6

Dopamine agonist

Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively.

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For laboratory research use only. We do not sell to patients.

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Biological Activity

Target & Activity

Target Activity Value
Dopamine receptor

Cellular Effect

Cell Line Activity Value Description Reference
CHO EC50 0.7 nM Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as increase of forskolin-induced cAMP production after 20 mins [PMID: 24296012]
CHO EC50 28 nM Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins [PMID: 24296012]
HEK-293T EC50 3.2 nM Agonist activity at human D2S receptor expressed in HEK293T cell membranes coexpressing Galphao1 assessed as induction of nucleotide exchange preincubated for 30 mins followed by addition of [35S]GTPgammaS measured after 30 mins by [35S]GTPgammaS binding [PMID: 28489379]
HEK-293T EC50 4.1 nM Partial agonist activity at human D2SR expressed in HEK293T cells co-expressing (EA)beta-arrestin2 assessed as induction of beta-arrestin2 recruitment after 5 hrs by chemiluminescence assay [PMID: 28489379]
HEK-293T EC50 4.4 nM Partial agonist activity at human D2SR expressed in HEK293T cells co-expressing (EA)beta-arrestin2 and GRK2 assessed as induction of beta-arrestin2 recruitment after 5 hrs by chemiluminescence assay [PMID: 28489379]

Specifications

Manufacturer Adooq Bioscience
Actions Agonist
CAS Number 99755-59-6
Applications Dopamine agonist
Formula C19H25NOS
Molecular Weight 315.47
SMILES
CCCN(CCC1=CC=CS1)[C@H]2CCC3=C(C2)C=CC=C3O

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 58 mg/mL (183.85 mM)
Water Insoluble
Ethanol 58 mg/mL (183.85 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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