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Salirasib

Name: Salirasib
Brand: Adooq Bioscience
SKU: A11572
Availability: InStock

Cat. No. A11572 CAS 162520-00-5

PPMTase inhibitor

Salirasib is an inhibitor of prenylated protein methyltransferase (PPMTase) with Ki value of 2.6 uM.

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Biological Activity

Target & Activity

Target	Activity	Value
PPMTase	Ki	2.6 μM

Cellular Effect

Cell Line	Activity	Value	Description	Reference
Bel-7402	IC50	76.13 μM	Cytotoxicity against human Bel7402 cells after 48 hrs by MTT based ELISA	[PMID: 21504204]
BXPC-3	EC50	> 20 μM	Cytotoxicity against human BxPC3 cells after 48 hrs by fluorescence assay	[PMID: 24852279]
EJ	IC50	47.6 μM	Cytotoxicity against human EJ cells after 48 hrs by MTT assay	[PMID: 24300920]
EJ	IC50	48.6 μM	Cytotoxicity against human EJ cells assessed as inhibition of cell growth by MTT assay	[PMID: 32791404]
HEK293	EC50	0.8 μM	Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay	[PMID: 30878828]
HEK293	EC50	7 μM	Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-3/acetoxymethyl ester dye based FLIPR analysis	[PMID: 30878828]
Hep 3B2	IC50	63.75 μM	Cytotoxicity against human Hep3B cells after 48 hrs by MTT based ELISA	[PMID: 21504204]
HepG2	IC50	107.51 μM	Cytotoxicity against human HepG2 cells after 48 hrs by MTT based ELISA	[PMID: 21504204]
HepG2	IC50	48.6 μM	Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth by MTT assay	[PMID: 32791404]
MCF7	IC50	46.75 μM	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 20435479]
MCF7	IC50	48.6 μM	Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth by MTT assay	[PMID: 32791404]
MCF7	IC50	49.1 μM	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 24300920]
MDA-MB-231	IC50	51.22 μM	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 20435479]
MEF	IC50	14.3 μM	Cytotoxicity against icmt-double mutant MEF cells after 5 days by MTT assay	[PMID: 22754607]
MEF	IC50	15.3 μM	Cytotoxicity against icmt-positive MEF cells after 5 days by MTT assay	[PMID: 22754607]
MIA PaCa-2	EC50	> 20 μM	Cytotoxicity against human MIAPaCa2 cells harboring K-Ras mutant oncogene after 48 hrs by fluorescence assay	[PMID: 24852279]
NCI-H460	IC50	48.6 μM	Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell growth by MTT assay	[PMID: 32791404]
NCI-H460	IC50	49.2 μM	Cytotoxicity against human H460 cells after 48 hrs by MTT assay	[PMID: 24300920]
PANC-1	IC50	35 μM	Cytotoxicity against human PANC1 cells after 5 to 7 days	[PMID: 19072665]
PANC-1	IC50	53.6 μM	Cytotoxicity against human PANC1 cells after 48 hrs by MTT assay	[PMID: 24300920]

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	162520-00-5
Applications	PPMTase inhibitor
Formula	C₂₂H₃₀O₂S
Molecular Weight	358.54
Synonyms	S-Farnesylthiosalicylic acid; Farnesyl Thiosalicylic Acid; FTS
SMILES	CC(=CCCC(=CCCC(=CCSC1=CC=CC=C1C(=O)O)C)C)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.