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SAR131675

Name: SAR131675
Brand: Adooq Bioscience
SKU: A13377
Availability: InStock

Cat. No. A13377 CAS 1433953-83-3

VEGFR3 Inhibitor

SAR131675, a potent and selective VEGFR-3-TK inhibitor with antilymphangiogenic, antitumoral, and antimetastatic activities.

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Biological Activity

Target & Activity

Target	Activity	Value
VEGFR3 (Cell-free assay)		23 nM

Cellular Effect

Cell Line	Activity	Value	Description	Reference
BaF3	GI50	> 25 μM	Growth inhibition of mouse BA/F3 cells assessed as inhibition of cell growth incubated for 72 hrs by Cell-titer-Glo assay	[PMID: 31513411]
MDA-MB-231	IC50	> 50 μM	Anticancer activity against human MDA-MB-231 cells assessed as cell viability incubated for 48 hrs by MTT assay	[PMID: 34351741]
MDA-MB-436	IC50	> 50 μM	Anticancer activity against human MDA-MB-436 cells assessed as cell viability incubated for 48 hrs by MTT assay	[PMID: 34351741]

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1433953-83-3
Applications	VEGFR3 Inhibitor
Formula	C₁₈H₂₂N₄O₄
Molecular Weight	358.29
SMILES	CCN1C(=C(C(=O)C2=C1N=C(C=C2)C#C[C@](C)(COC)O)C(=O)NC)N

Storage & Solubility

In Vitro Solubility

Reported Solubility

Solvent	Reported Solubility
DMSO	29 mg/mL (80.91 mM)
Water	Insoluble
Ethanol	Insoluble

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

In Vivo Preparation

Concentration: 2 mg/mL
Vehicle: 5% DMSO+30% PEG 300+5% Tween 80+ddH2O

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.