SAR156497

Aurora Kinase inhibitor

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Catalog No. A14382

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
SAR156497 5mg A14382-5
$350.00
SAR156497 10mg A14382-10
$600.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SAR156497 is an exquisitely selective Aurora A, B, and C inhibitor with in vitro and in vivo efficacy with IC50 = 0.5 nM (Aurora A), 1 nM (Aurora B / incenp), 3 nM (Aurora C / incenp) respectively SAR156497 combines high in vitro potency with satisfactory metabolic stability and limited CYP3A4 and PDE3 inhibition.

SAR156497

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Chemical Information

Catalog Num A14382
Actions Inhibitor
M. Wt 468.5
Formula C27H24N4O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1256137-14-0
Synonyms SAR-156497, SAR 156497
SMILES code O=C(C1=C2NC3=C(C(CCC3)=O)[[email protected]@H](C4=CC=CC(OC5=NC6=CC=CC=C6N5)=C4)C2=CN1)OCC
Chemical Name (S)-ethyl 9-(3-((1H-benzo[d]imidazol-2-yl)oxy)phenyl)-8-oxo-4,5,6,7,8,9-hexahydro-2H-pyrrolo[3,4-b]quinoline-3-carboxylate

Biological Activity

Description
SAR156497 is an exquisitely selective Aurora A, B, and C inhibitor with in vitro and in vivo efficacy with IC50 = 0.5 nM (Aurora A), 1 nM (Aurora B / incenp), 3 nM (Aurora C / incenp) respectively SAR156497 combines high in vitro potency with satisfactory metabolic stability and limited CYP3A4 and PDE3 inhibition.

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