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|Storage||at -20°C 3 years Powder|
|Synonyms||SAR-156497, SAR 156497|
|SMILES code||O=C(C1=C2NC3=C(C(CCC3)=O)[[email protected]@H](C4=CC=CC(OC5=NC6=CC=CC=C6N5)=C4)C2=CN1)OCC|
|Chemical Name||(S)-ethyl 9-(3-((1H-benzo[d]imidazol-2-yl)oxy)phenyl)-8-oxo-4,5,6,7,8,9-hexahydro-2H-pyrrolo[3,4-b]quinoline-3-carboxylate|
|SAR156497 is an exquisitely selective Aurora A, B, and C inhibitor with in vitro and in vivo efficacy with IC50 = 0.5 nM (Aurora A), 1 nM (Aurora B / incenp), 3 nM (Aurora C / incenp) respectively SAR156497 combines high in vitro potency with satisfactory metabolic stability and limited CYP3A4 and PDE3 inhibition.|
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