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SB 743921


KSP Inhibitor

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Catalog No. A10828

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
SB 743921 5mg A10828-5

Regular Price: $120.00

Special Price: $108.00

SB 743921 10mg A10828-10

Regular Price: $220.00

Special Price: $198.00

SB 743921 50mg A10828-50

Regular Price: $670.00

Special Price: $603.00

SB 743921 100mg A10828-100

Regular Price: $950.00

Special Price: $855.00

SB 743921 10mM * 1mL in DMSO A10828-10mM-D

Regular Price: $225.00

Special Price: $202.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SB 743921, a second generation KSP inhibitor, is a highly potent and active therapeutic in preclinical models of cancer.

SB 743921

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Chemical Information

Catalog Num A10828
Actions Inhibitor
M. Wt 553.5
Formula C31H33N2O3.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 940929-33-9
Synonyms SB-743921, SB743921
SMILES code CC1=CC=C(C=C1)C(=O)N(CCCN)[[email protected]@H](C2=C(C(=O)C3=C(O2)C=C(C=C3)Cl)CC4=CC=CC=C4)C(C)C.Cl
Chemical Name N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methylbenzamide hydrochloride

Biological Activity

SB 743921, a second generation KSP inhibitor, is a highly potent and active therapeutic in preclinical models of cancer.
Target Value
KSP(MX1cells)IC50: 0.06nM
KSP(Colo205cells)IC50: 0.07nM
KSPki: 0.1nM
KSP(SKOV3cells)IC50: 0.2nM
KSP(MV522cells)IC50: 1.7nM
KSP(P388cells)IC50: 14.4nM


Solubility (25°C) * In vitro DMSO 111 mg/mL (200.53 mM)
Water 22 mg/mL (39.74 mM)
Ethanol 111 mg/mL (200.53 mM)
In vivo Saline pH5.0 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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