Fig. 1 · Structure
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SCH 442416
Cat. No.
A12695
CAS
316173-57-6
A2A Receptor Antagonist
SCH 442416 is a selective adenosine A2A receptor antagonist; binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 nM respectively). Displays > 23000-fold selectivity for hA2A over hA1 in vitro with minimal affinity for hA2B and hA3 receptors (IC50 > 10 μM).
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 316173-57-6 |
| Applications | A2A Receptor Antagonist |
| Formula | C20H19N7O2 |
| Molecular Weight | 389.42 |
| SMILES | COC1=CC=C(C=C1)CCCN2C3=C(C=N2)C4=NC(=NN4C(=N3)N)C5=CC=CO5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 72 mg/mL (184.89 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.