SCH 900776 (MK-8776)

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Chk1 inhibitor

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Catalog No. A11167

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
SCH 900776 5mg A11167-5

Regular Price: $90.00

Special Price: $76.50

SCH 900776 10mg A11167-10

Regular Price: $160.00

Special Price: $136.00

SCH 900776 50mg A11167-50

Regular Price: $450.00

Special Price: $382.50

SCH 900776 100mg A11167-100

Regular Price: $750.00

Special Price: $637.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. It specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.

SCH 900776 (MK-8776)

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Chemical Information

Catalog Num A11167
Actions Inhibitor
M. Wt 376.25
Formula C15H18BrN7
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 891494-63-6
Synonyms SCH-900776, MK-8776, MK8776, MK 8776
SMILES code CN1C=C(C=N1)C2=C3N=C(C(=C(N3N=C2)N)Br)[[email protected]]4CCCNC4
Chemical Name (R)-6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine

Biological Activity

Description

SCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. It specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.

Solubility

Solubility (25°C) * In vitro DMSO 3 mg/mL (7.97 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 4% DMSO/30% propylene glycol 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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